Prof. Xiao-Hua Qin

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Development of a Heterocellular Human Bone Organoid for Precision Medicine and Treatment

Our goal is to establish a heterocellular 3D printed bone organoid model comprising all major bone cell types (osteoblasts, osteocytes, osteoclasts) to recapitulate bone remodeling units in an in vitro system. The organoids will be produced with the human cells, as they could represent human pathophysiology better than animal models, and eventually could replace them. These in vitro models could be used in the advancement of next-generation personalised treatment strategies. Our tools are different kinds of 3D bioprinting platforms, bio-ink formulations, hydrogels, mol-bioassays, and time-lapsed image processing of micro-CT scans.

Keywords

3D printing, bone organoids, co-culture, bioreactor, hydrogels, drug testing

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Semester Project , Internship , Bachelor Thesis , Master Thesis , ETH Zurich (ETHZ)

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Published since: 2025-03-24 , Earliest start: 2022-08-01 , Latest end: 2025-11-30

Organization Müller Group / Laboratory for Bone Biomechanics

Hosts Steffi Chris

Topics Engineering and Technology , Biology

Exploring the Mechanoregulation of Bone Regeneration

In over 100 years, the remarkable ability of bone to adapt to its mechanical environment has been a source of scientific fascination. Bone regeneration has been shown to be highly dependent on the mechanical environment at the fracture site. It has been demonstrated that mechanical stimuli can either accelerate or impede regeneration. Despite the fundamental importance of the mechanical environment in influencing bone regeneration, the molecular mechanisms underlying this phenomenon are complex and poorly understood.

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Bone, Mechanobiology, Spatial transcriptomics, Gene expression, Finite element modelling, Image processing

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Semester Project , Internship , Bachelor Thesis , Master Thesis

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Published since: 2025-03-23 , Earliest start: 2024-11-01 , Latest end: 2025-08-31

Organization Müller Group / Laboratory for Bone Biomechanics

Hosts Mathavan Neashan

Topics Medical and Health Sciences , Engineering and Technology

Exploring the 3D Mineralization Behavior in Material-Induced Osteoinduction Through a Multiscale Micro-CT Imaging Approach

The project aims at investigating material-induced osteoinduction using the available mouse model of orthotopic or ectopic bone graft substitute (BGS) application. Through the 3D-3D registration of ex vivo and in vivo multiscale micro-CT images, crucial 3D mineralization behavior of the BGS can be investigated.

Keywords

Femur, Bone Graft Substitute, Critical Size Defect, Osteoinduction, in vivo, micro-CT, 3D-3D Image Registration, Image Analysis, Image Processing, Python, Computational

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Semester Project , Bachelor Thesis , Master Thesis

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Published since: 2025-03-11 , Earliest start: 2025-04-01 , Latest end: 2026-01-31

Organization Müller Group / Laboratory for Bone Biomechanics

Hosts Lindenmann Sara

Topics Medical and Health Sciences , Engineering and Technology

Unraveling Calcium Dynamics and Immune Interactions in Bone Graft Substitute Environments through Advanced Ratiometric Imaging

This project endeavors to explore the dynamic interplay among calcium ions, bone graft substitutes, and resident immune cells in both orthotopic and ectopic environments, employing advanced ratiometric imaging techniques.

Keywords

Bone Graft Substitute, Calcium, Ratiometric Imaging, Immune Cells, in vitro, in vivo, Intravital Microscopy

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Semester Project , Internship , Bachelor Thesis , Master Thesis

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Published since: 2024-12-24 , Earliest start: 2024-10-01 , Latest end: 2025-06-30

Organization Müller Group / Laboratory for Bone Biomechanics

Hosts Wissmann Stefanie

Topics Engineering and Technology , Biology

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