Student Projects
Tissue Engineering Approaches to Study Tendon Injury, Disease, and Therapy
Join a dynamic research team at the intersection of biomechanics, tissue engineering, and cell biology. This project offers hands-on training in state-of-the-art methods to investigate how tendon tissue responds to injury, disease processes, and mechanical stimulation during exercise-based therapy.
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Tendon biology, tissue engineering, mechanobiology, cell culture, microscopy, regenerative medicine, exercise therapy, inflammation, ECM remodeling
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Master Thesis
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Published since: 2025-04-15 , Earliest start: 2025-05-01 , Latest end: 2026-12-31
Organization Snedeker Group / Laboratory for Orthopaedic Biomechanics
Hosts Snedeker Jess, Prof.
Topics Engineering and Technology
Experimental and Numerical Investigation of Direction-Dependent Flow Resistance in Engineered Geometries
Controlling fluid flow is essential in various natural and engineering systems, with geometry playing a fundamental role in shaping fluid behavior. However, the interaction between geometry and flow behavior remains a complex phenomenon, primarily governed by the flow regime and fluid material properties. Certain geometries, whether naturally occurring or engineered, induce direction-dependent flow resistance, causing variations in velocity and flow rate in opposite directions. One well-known example of such engineered geometries is the Tesla valve—a passive device without moving parts, designed to create asymmetric flow resistance, particularly at high Reynolds numbers. This structure acts like a fluidic diode, offering greater resistance to flow in one direction by generating turbulent vortices and flow separations while allowing smoother movement in the opposite direction. This effect is quantified by diodicity, which represents the ratio of pressure drop in the reverse direction to that in the forward direction, providing a measure of the valve's asymmetric resistance. However, this direction dependence is limited at lower velocities. We have designed two sets of geometries that effectively induce directional flow resistance within high and low fluid flow velocities. This Master’s thesis project aims to experimentally investigate the impact of different flow obstruction designs on direction-dependent resistance in rectangular channels and semicircular arc segments. The student will, together with their direct supervisor, design and construct an experimental setup for the reliable measurement of flow and diodicity. This project offers an excellent opportunity to gain expertise in fluid dynamics, experimental testing, numerical modeling, and additive manufacturing, with applications in biomedical systems. Students with a background in mechanical engineering, fluid dynamics, or related fields are encouraged to apply. Prior experience with COMSOL Multiphysics is beneficial but not mandatory.
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Master Thesis
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Published since: 2025-04-15 , Earliest start: 2025-06-01 , Latest end: 2025-12-01
Organization Musculoskeletal Biomechanics
Hosts Mosayebi Mahdieh
Topics Engineering and Technology
Development of a Heterocellular Human Bone Organoid for Precision Medicine and Treatment
Our goal is to establish a heterocellular 3D printed bone organoid model comprising all major bone cell types (osteoblasts, osteocytes, osteoclasts) to recapitulate bone remodeling units in an in vitro system. The organoids will be produced with the human cells, as they could represent human pathophysiology better than animal models, and eventually could replace them. These in vitro models could be used in the advancement of next-generation personalised treatment strategies. Our tools are different kinds of 3D bioprinting platforms, bio-ink formulations, hydrogels, mol-bioassays, and time-lapsed image processing of micro-CT scans.
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3D printing, bone organoids, co-culture, bioreactor, hydrogels, drug testing
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Semester Project , Internship , Bachelor Thesis , Master Thesis , ETH Zurich (ETHZ)
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Published since: 2025-03-24 , Earliest start: 2022-08-01 , Latest end: 2025-11-30
Organization Müller Group / Laboratory for Bone Biomechanics
Hosts Steffi Chris
Topics Engineering and Technology , Biology
Exploring the Mechanoregulation of Bone Regeneration
In over 100 years, the remarkable ability of bone to adapt to its mechanical environment has been a source of scientific fascination. Bone regeneration has been shown to be highly dependent on the mechanical environment at the fracture site. It has been demonstrated that mechanical stimuli can either accelerate or impede regeneration. Despite the fundamental importance of the mechanical environment in influencing bone regeneration, the molecular mechanisms underlying this phenomenon are complex and poorly understood.
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Bone, Mechanobiology, Spatial transcriptomics, Gene expression, Finite element modelling, Image processing
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Semester Project , Internship , Bachelor Thesis , Master Thesis
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Published since: 2025-03-23 , Earliest start: 2024-11-01 , Latest end: 2025-08-31
Organization Müller Group / Laboratory for Bone Biomechanics
Hosts Mathavan Neashan
Topics Medical and Health Sciences , Engineering and Technology
Exploring the 3D Mineralization Behavior in Material-Induced Osteoinduction Through a Multiscale Micro-CT Imaging Approach
The project aims at investigating material-induced osteoinduction using the available mouse model of orthotopic or ectopic bone graft substitute (BGS) application. Through the 3D-3D registration of ex vivo and in vivo multiscale micro-CT images, crucial 3D mineralization behavior of the BGS can be investigated.
Keywords
Femur, Bone Graft Substitute, Critical Size Defect, Osteoinduction, in vivo, micro-CT, 3D-3D Image Registration, Image Analysis, Image Processing, Python, Computational
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Semester Project , Bachelor Thesis , Master Thesis
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Published since: 2025-03-11 , Earliest start: 2025-04-01 , Latest end: 2026-01-31
Organization Müller Group / Laboratory for Bone Biomechanics
Hosts Lindenmann Sara
Topics Medical and Health Sciences , Engineering and Technology
PhD position in tissue microfabrication
The Biomaterials Engineering (BME) group of Professor Xiao-Hua Qin is hiring an ERC-funded PhD student in tissue microfabrication.
Keywords
micro-devices, tissue engineering, biomechanics, bone, additive manufacturing
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PhD Placement , ETH Zurich (ETHZ)
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Published since: 2025-01-03 , Earliest start: 2024-09-01 , Latest end: 2025-01-01
Applications limited to EPFL - Ecole Polytechnique Fédérale de Lausanne , ETH Zurich , IBM Research Zurich Lab , Paul Scherrer Institute , Wyss Translational Center Zurich , University of Zurich , University of Geneva , University of Berne , University of Basel , Empa , Eberhard Karls Universität Tübingen , European Molecular Biology Laboratory (EMBL) , Humboldt-Universität zu Berlin , Ludwig Maximilians Universiy Munich , Max Planck Society , TU Dresden , Universität Ulm , TU Darmstadt , TU Berlin , Technische Universität München , Technische Universität Hamburg , RWTH Aachen University , University of Erlangen-Nuremberg , University of Hamburg , University of Konstanz , Imperial College London , University of Cambridge , University of Oxford , University of Nottingham , UCL - University College London , Delft University of Technology , Radboud University Nijmegen , Utrecht University , European Molecular Biology Laboratory , Massachusetts Institute of Technology , Peking University , Princeton University , Technical University of Denmark , The University of Tokyo , University of California, Berkeley , University of Toronto , Yale University , Uppsala Universitet , University of California, San Diego , National University of Singapore , IDEA League , Harvard , Stanford University , The University of Edinburgh , Tsinghua University , Université de Strasbourg , University of Queensland , The University of Melbourne
Organization Qin Group / Biomaterials Engineering
Hosts Qin Xiao-Hua, Prof. Dr.
Topics Engineering and Technology
Unraveling Calcium Dynamics and Immune Interactions in Bone Graft Substitute Environments through Advanced Ratiometric Imaging
This project endeavors to explore the dynamic interplay among calcium ions, bone graft substitutes, and resident immune cells in both orthotopic and ectopic environments, employing advanced ratiometric imaging techniques.
Keywords
Bone Graft Substitute, Calcium, Ratiometric Imaging, Immune Cells, in vitro, in vivo, Intravital Microscopy
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Semester Project , Internship , Bachelor Thesis , Master Thesis
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Published since: 2024-12-24 , Earliest start: 2024-10-01 , Latest end: 2025-06-30
Organization Müller Group / Laboratory for Bone Biomechanics
Hosts Wissmann Stefanie
Topics Engineering and Technology , Biology