Student Projects

Identifying the causes of patellar instability

Patello-femoral joint (PFJ) instability is one of the most common knee problems in children and adolescents. In this project in collaboration with the University Children’s Hospital Basel, we aim to uncover the key factors contributing to PFJ instability and validate joint kinematics using a dynamic fluoroscope system.

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Patello-femoral joint instability, knee pain, joint kinematics, dynamic fluoroscope system

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Internship , Master Thesis

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Published since: 2026-05-06 , Earliest start: 2026-05-01 , Latest end: 2026-12-31

Applications limited to ETH Zurich , University of Zurich , University of Fribourg , University of Geneva , University of Berne , Berner Fachhochschule , Zurich University of Applied Sciences , University of Basel , University of St. Gallen , University of Lucerne , EPFL - Ecole Polytechnique Fédérale de Lausanne , Université de Neuchâtel , Humboldt-Universität zu Berlin , Eberhard Karls Universität Tübingen , Ludwig Maximilians Universiy Munich , Max Planck Society , Technische Universität München , Technische Universität Hamburg , RWTH Aachen University , TU Dresden , TU Berlin , TU Darmstadt , Ulm University , University of Cologne , University of Hamburg , University of Konstanz , University of Erlangen-Nuremberg , Universtity of Bayreuth , Imperial College London , UCL - University College London , University of Cambridge , University of Aberdeen , National Institute for Medical Research , University of Manchester , University of Leeds , University of Nottingham , University of Oxford , Delft University of Technology , Maastricht Science Programme , Radboud University Nijmegen , CNRS - Centre national de la recherche scientifique , Harvard , IDEA League , Istituto Italiano di Tecnologia , Massachusetts Institute of Technology , Politecnico di Milano , Princeton University , Stanford University , Technical University of Denmark , The Australian National University , The University of Edinburgh , University of Copenhagen , University of Toronto , University of Queensland , The University of Melbourne , Yale University , Uppsala Universitet , University College Dublin , Université de Strasbourg

Organization Neuromuscular Biomechanics

Hosts Gwerder Michelle

Topics Medical and Health Sciences , Engineering and Technology

Personalised musculoskeletal modelling for clinical decision making

This project aims to improve the accuracy of gait analysis–based surgical decision-making by integrating biplane X-ray data with motion capture to reduce errors from marker placement and bone deformities. It focuses on developing personalized musculoskeletal models and validating knee calibration methods, using clinical data and potentially advancing automated marker detection tools.

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Master Thesis

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Published since: 2026-05-06 , Earliest start: 2026-05-03 , Latest end: 2027-08-31

Applications limited to ETH Zurich , University of Basel

Organization Taylor Group / Dual-Plane Fluoroscope

Hosts Gwerder Michelle

Topics Medical and Health Sciences

Unraveling the Link Between Meniscal Extrusion and Tibiofemoral Contact Stability: A Multi-Parametric Analysis of Dynamic Trajectories and Cumulative Compressive Burden

Meniscal extrusion is a critical precursor to knee osteoarthritis, yet its specific impact on dynamic contact stability remains poorly understood. This project utilizes high-precision dual-fluoroscopy to investigate the correlation between meniscal lateral displacement and tibial compartment contact mechanics. We propose a comprehensive evaluation framework combining kinematic stability metrics (e.g., Excursion, Instantaneous Jitter, Convex Hull Area) with a novel Cumulative Compressive Deformation (CCD) index. By quantifying how meniscal failure exacerbates contact wandering and cumulative stress, this study aims to identify early biomechanical markers of cartilage degeneration.

Keywords

Meniscal Extrusion; Contact Stability; Cumulative Compressive Deformation (CCD); Dual-Fluoroscopy; Osteoarthritis.

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Semester Project , Internship , Master Thesis

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1. Background & Clinical Significance: The meniscus plays a pivotal role in load transmission and joint stabilization. However, meniscal lateral displacement (extrusion) compromises its "hoop stress" function, potentially leading to altered tibiofemoral kinematics. While static measurements of extrusion are common, the dynamic consequences—specifically how extrusion affects the stability of the contact interface during functional activities—are not fully characterized. Instability in contact location ("wandering contact") combined with excessive compression is hypothesized to accelerate cartilage failure. 2. Methodological Approach: This study employs high-speed dual-plane fluoroscopy to reconstruct 6DOF in vivo knee kinematics. We focus on the medial and lateral tibial compartments to quantify the relationship between meniscal health and contact mechanics through two primary dimensions: A. Quantification of Contact Stability (The "Wandering" Effect) To capture the dynamic fluctuation of the contact centroid on the tibial plateau, we calculate: Excursion & Range: Decomposed into Anteroposterior (AP) Range, Mediolateral (ML) Range, and Total Path Length. Increased excursion indicates a failure of the joint to maintain a stable pivot point. Dispersion & Variability: Instantaneous Jitter: High-frequency fluctuations in contact location, representing a loss of fine neuromuscular or mechanical control. Convex Hull Area: The area of the smallest polygon enclosing the contact trajectory, representing the total "footprint" of instability. B. Cumulative Compressive Burden (The "Squeezing" Effect) Beyond location, we assess the severity of loading using the Cumulative Compressive Deformation (CCD). This time-integrated metric sums the magnitude and duration of cartilage compression (defined as dynamic JSW falling below a reference threshold, e.g., 2.5 mm) throughout the stance phase. 3. Hypothesized Mechanism: We posit that greater meniscal lateral displacement correlates with reduced contact stability (larger convex hull and path length) and higher CCD values. This "double hit" of unstable shear forces and sustained compressive squeezing creates a distinct mechanical pathway for osteoarthritis initiation in the affected compartments.

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Published since: 2026-05-05 , Earliest start: 2026-03-05 , Latest end: 2026-09-30

Organization Knee Joint Articular Contact Kinematics

Hosts Jiang Ziang

Topics Medical and Health Sciences

Biomechanical Efficacy of Orthotic Footwear Interventions in Knee Osteoarthritis: A Multi-Modal Analysis of Static Loading and Dynamic Contact Mechanics

This study evaluates the therapeutic efficacy of three footwear conditions, including Control, Lateral Wedge Insoles (LWI), and Variable Stiffness Shoes (VSS), on the medial tibiofemoral compartment. By integrating high-speed dual-fluoroscopy with force plate kinetics, we analyze joint mechanics across static (unloaded vs. loaded) and dynamic states (gait cycle). Specifically, we investigate whether reductions in the external Knee Adduction Moment (KAM) at 1st and 2nd peaks translate into tangible improvements in internal contact patterns, such as medial Joint Space Width (JSW) recovery and contact location shifts. This project aims to cross-validate kinetic surrogates with in vivo kinematic ground truth to determine the optimal intervention strategy.

Keywords

Knee Osteoarthritis; Conservative Treatment; Kinetics; Dual-Fluoroscopy; Joint Space Width (JSW); Contact Location.

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Semester Project , Internship , Master Thesis

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1. Background & Rationale Conservative interventions like Lateral Wedge Insoles (LWI) and Variable Stiffness Shoes (VSS) are designed to unload the medial knee compartment. However, clinical efficacy is often inferred solely from the external Knee Adduction Moment (KAM). It remains unclear whether reductions in KAM strictly correspond to favorable changes in the internal mechanical environment (e.g., increased JSW or beneficial shifts in contact location). This study bridges the gap between external kinetics and internal in vivo kinematics. 2. Experimental Conditions Subjects will undergo testing under three randomized conditions: Control: Standard neutral footwear. LWI: Footwear with a lateral wedge (e.g., 5-degree inclination). VSS: Footwear with variable stiffness soles designed to alter the center of pressure. 3. Analysis Framework The assessment is divided into two distinct phases to capture the full spectrum of mechanical response: A. Static Load Response (The "Stiffness" Check) We compare joint configurations between Non-Weight Bearing (NWB) and Full Weight Bearing (FWB) standing postures. Objective: To quantify the immediate deformation of cartilage and meniscus under static load across different shoes. Metrics: Change in static JSW and static contact centroid position. B. Dynamic Gait Analysis (The "Functional" Check) We focus on two critical events during the stance phase of gait: 1st Peak KAM (Early Stance): Maximum loading acceptance. 2nd Peak KAM (Late Stance): Propulsion phase. Objective: To capture the instantaneous contact patterns at moments of peak external load. 4. Mechanistic Validation & Outcome Measures A key innovation of this project is the cross-validation of data sources: Internal Kinematics (Dual-Fluoro): Contact Location: Does the centroid shift laterally (away from the worn medial area)? Dynamic JSW: Is the minimum joint clearance preserved? Contact Trajectory: Does the path length shorten (indicating better stability)? External Kinetics (Force Plates): KAM Reduction: Percentage decrease in peak moments. Correlation: We will determine if ΔKAM significantly correlates with ΔJSW and ΔContactLocation. This verifies if KAM is a reliable proxy for internal joint unloading in these specific footwear designs.

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Published since: 2026-05-05 , Earliest start: 2026-03-05 , Latest end: 2026-09-30

Organization Knee Joint Articular Contact Kinematics

Hosts Jiang Ziang

Topics Medical and Health Sciences

Generation of decellularized extracellular matrix derived from adipose tissue

In this project, the student will utilize tissue engineering and biomaterials techniques to generate and characterize decellularized extracellular matrix (dECM) derived from adipose tissue. Our lab is interested in developing biologically relevant hydrogel systems that recapitulate native tissue microenvironments for use in 3D tissue models.

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tissue engineering, decellularized extracellular matrix, hydrogel

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Semester Project , Internship , Master Thesis , ETH Zurich (ETHZ)

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Published since: 2026-04-29 , Earliest start: 2026-06-01 , Latest end: 2027-01-01

Organization Maerz Laboratory / Musculoskeletal Bioengineering

Hosts Bevc Kajetana

Topics Engineering and Technology , Biology

Spatial Proteomics of Mechanically-Driven Bone Healing

Bone healing is profoundly influenced by its mechanical environment. Advances in spatial proteomics now allow us to map protein expression within intact tissue and directly relate it to local biomechanical cues. The Laboratory for Bone Biomechanics is developing a new line of research within spatial mechanomics (DOI: 10.1126/sciadv.adp8496), integrating spatially resolved proteomic data with in silico models of the mechanical environment at fracture sites. This approach enables us to investigate, at cellular resolution, how mechanical forces shape protein-level signalling during bone repair.

Keywords

Bone, Mechanobiology, Spatial Proteomics, Protein Expression, Aging, Sex Differences, Mechanical Loading, Finite Element Modelling, Image Analysis

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Semester Project , Internship , Bachelor Thesis , Master Thesis

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Published since: 2026-04-28 , Earliest start: 2025-12-01 , Latest end: 2026-12-31

Organization Müller Group / Laboratory for Bone Biomechanics

Hosts Mathavan Neashan

Topics Medical and Health Sciences , Engineering and Technology , Biology

From Skin to Bone: Validating a Skin-Marker Based 6DOF Knee Motion Capture Pipeline Using Biplanar Video-Radiography

Skin marker-based motion capture is widely used to measure knee kinematics during gait, but soft-tissue artefacts limit its accuracy. This project validates MiKneeSoTA, a pipeline minimising these artefacts, against ground-truth bone motion from dynamic biplanar video-radiography. The REFRAME approach is additionally implemented to reconcile the two systems' reference frames. Together, these steps assess the viability of a fully marker-based 6DOF tibiofemoral kinematics pipeline.

Keywords

gait analysis; joint kinematics, knee; motion capture

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Semester Project , Internship , Master Thesis

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**Type:** Master's Thesis or Research Internship **Background & Motivation** Accurate measurement of tibiofemoral joint kinematics during gait is essential for understanding healthy movement and informing clinical decision-making. Skin marker-based optical motion capture is widely used but subject to considerable soft-tissue artefact, which can substantially distort estimated bone motion. Validating marker-based methods against ground-truth bone motion is therefore critical. **Project Description** This project involves two interconnected objectives: 1 - Validation of MiKneeSoTA MiKneeSoTA (Minimise Knee Soft-Tissue Artefacts) is a pipeline for estimating tibiofemoral joint kinematics from optical skin markers, combining an augmented marker set with a cylinder-based biomechanical model and frame-by-frame optimisation to minimise non-rigid segment deformations [Einfeldt et al., 2024: https://doi.org/10.1038/s41598-024-71409-z; Ortigas-Vásquez et al., 2025: https://doi.org/10.3389/fbioe.2025.1530365]. This project will validate the method's accuracy by comparing its kinematic outputs against ground-truth bone motion obtained from dynamic biplanar video-radiography, which tracks bone positions with high spatial precision during movement. 2 - Implementation and validation of REFRAME REFRAME (REference FRame Alignment MEthod) is a computational approach for aligning local segment reference frames across, e.g., measurement systems [Ortigas-Vásquez et al., Part I: https://doi.org/10.1038/s41598-025-86137-1; Part II: https://doi.org/10.1038/s41598-024-76275-3]. It will be implemented here to reconcile the coordinate systems of the video-radiography and optical motion capture setups. The proposed frame transformations will then be validated against reference frame differences measured directly in a common global space. **Data** This project will leverage existing data from healthy participants, including simultaneous dynamic biplanar video-radiography and optical skin marker motion capture recordings during level walking. Students may be required to support with manual image registration as part of their projects, but the focus will be on data analysis and processing. **Your Profile** - Master's student with a background in Biomechanics, Human Movement Sciences, Biomedical Engineering, etc. - Interest in gait analysis - Basic programming experience in MATLAB would be highly beneficial - Familiarity with rigid body kinematics is an advantage

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Published since: 2026-04-20 , Earliest start: 2026-05-18

Organization Clinical Movement Biomechanics

Hosts Ortigas Vasquez Ariana

Topics Medical and Health Sciences , Engineering and Technology

Biomechanical Investigation of a Self-Lubricating Hip Prosthesis in the Presence of an Articulating Femoral Head

Current joint replacements cannot replicate the natural weeping lubrication mechanism found in cartilage, resulting in a typical implant lifespan of about 15–20 years due to friction and wear, often leading to revision surgery, particularly in younger patients. Inspired by the load-induced self-pressurization behavior of articular cartilage, we aim to design and develop a novel self-lubricating hip prosthesis that mimics this physiological lubrication mechanism. We have developed a self-lubricating hip prosthesis model in COMSOL Multiphysics that integrates three coupled multiphysics phenomena: Fluid–Structure Interaction, Free and Porous Media Flow, and Poroelasticity. In this semester project, the computational model will be extended by incorporating the femoral head to represent the physiological articulating joint configuration more realistically. The study will investigate how the presence of the femoral head influences fluid pressure distribution, fluid transport, and lubrication behavior within the prosthesis under physiological loading conditions. In addition, the effect of the non-Newtonian rheological behavior of synovial fluid on the lubrication response of the system will be examined. Students with a background in mechanical engineering, particularly in fluid dynamics, are encouraged to apply. Prior experience with COMSOL Multiphysics is beneficial but not mandatory.

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Published since: 2026-04-09 , Earliest start: 2026-05-01 , Latest end: 2026-08-01

Organization Musculoskeletal Biomechanics

Hosts Mosayebi Mahdieh

Topics Engineering and Technology

NAD+ metabolism in fibroblast inflammation and fibrosis

This project is focused on the metabolic changes in synovial fibroblasts during the development of inflammation and fibrosis during osteoarthritis.

Keywords

NAD, osteoarthritis, fibroblast, cell culture, molecular biology

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Semester Project , Bachelor Thesis , Master Thesis , ETH Zurich (ETHZ)

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Published since: 2026-03-18 , Earliest start: 2026-05-01 , Latest end: 2027-05-31

Organization Maerz Laboratory / Musculoskeletal Bioengineering

Hosts DeJulius Carlisle

Topics Biology

Biomechanical Investigation into the Loading-Response Mechanisms and Factors Underlying Non-Response to Variable Stiffness Shoes in Knee Osteoarthritis

Lateral Wedge Insoles (LWI) are a common intervention for medial Knee Osteoarthritis (KOA) but suffer from a high non-response rate (25-50%) and potential ankle instability risks. Variable Stiffness Shoes (VSS) offer a novel approach by inducing dynamic Center of Pressure (COP) shifts via gradient sole modulus. However, the internal joint mechanisms determining patient responsiveness to VSS remain unclear. This study utilizes high-precision dual-fluoroscopy combined with motion capture to investigate the root causes of "non-response," hypothesizing that subtalar joint stiffness and Foot Progression Angle (FPA) mismatch are critical limiting factors. We aim to quantify the dynamic minimum Joint Space Width (mJSW) recovery and compare the ankle safety profile of VSS against LWI, providing a theoretical basis for personalized orthotic design.

Keywords

Knee Osteoarthritis (KOA); Variable Stiffness Shoes (VSS); Lateral Wedge Insole (LWI); Non-responder; Subtalar Joint Stiffness; Dual-Fluoroscopy; Dynamic Joint Space Width (mJSW); Foot Progression Angle (FPA); Ankle Stability.

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Semester Project , Internship , Master Thesis

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1. Background & Motivation Medial compartment Knee Osteoarthritis (KOA) is a leading cause of disability. While Lateral Wedge Insoles (LWI) are widely prescribed to reduce the Knee Adduction Moment (KAM) by shifting the Center of Pressure (COP) laterally, clinical efficacy is inconsistent, with 25-50% of patients classified as "non-responders." Emerging evidence suggests this failure may stem from the foot-ankle complex's biomechanical characteristics—specifically subtalar joint stiffness or inadequate foot eversion compensation—which prevent the effective lateralization of the COP. Variable Stiffness Shoes (VSS) utilize a material gradient to induce COP shifts, theoretically requiring less subtalar kinematic compensation than geometric wedges. However, non-response remains a challenge, and conventional gait analysis lacks the precision to observe internal knee contact mechanics or decouple the interference of foot stiffness and progression angles on force transmission. Furthermore, while LWI reduces knee load, it often causes "Moment Redistribution," increasing ankle eversion moments and the risk of instability. It remains unknown whether VSS can mitigate these adverse effects. 2. Research Hypotheses Mechanism of Non-Response: The failure of VSS intervention is primarily attributed to excessive stiffness in the patient's subtalar joint/foot-ankle complex, restricting lateral COP displacement. Additionally, a spatial mismatch between the patient's Foot Progression Angle (FPA) (e.g., excessive toe-out) and the pre-set stiffness gradient zone negates the unloading effect. Safety & Stability: Compared to LWI, VSS will achieve KAM reduction with a significantly smaller increase in ankle eversion moment and will demonstrate superior gait stability (e.g., Margin of Stability) comparable to neutral shoes. 3. Methods 3.1 Participants: 15 patients with medial KOA (Kellgren-Lawrence grades I-IV) will be recruited. Exclusion criteria include prior lower limb surgery, rheumatoid arthritis, or neurological disorders. All subjects will undergo MRI for 3D bone modeling. 3.2 Intervention Design: VSS: 3D-printed soles with a 1:6 medial-to-lateral stiffness ratio, defined by the lateral 95% confidence interval of COP trajectories from a 600-person dataset, featuring a rocker sole. LWI: Standard 5° full-length lateral wedge. Control: Neutral flat shoes with identical upper design. 3.3 Data Acquisition (Multi-Modal): Dynamic Dual-Fluoroscopy: Captures internal knee motion during treadmill gait. Optical Motion Capture: Records whole-body kinematics via reflective markers. Kinetics: Force plates measure Ground Reaction Forces (GRF), while in-shoe pressure sensors (e.g., Pedar/Tekscan) record high-resolution COP trajectories. 3.4 Data Processing & Analysis: 6-DOF Knee Kinematics: 2D-3D registration of MRI models to fluoroscopic images will reconstruct in vivo stance phase motion. The primary outcome for "response" is the increase in Dynamic Minimum Joint Space Width (mJSW) and shifts in Contact Excursion. Foot-Ankle Biomechanics: Analysis of subtalar joint Range of Motion (ROM) and the spatial alignment between FPA and the VSS stiffness boundary. Stability Assessment: Calculation of Peak Ankle Eversion Moment, Margin of Stability (MoS), and COM-COP lateral separation to assess fall risk. 3.5 Statistical Analysis: Repeated Measures ANOVA will compare biomechanical parameters across conditions. Pearson correlation will examine relationships between foot flexibility/FPA and the magnitude of knee unloading (ΔmJSW). 4. Expected Outcomes & Innovation Precision Mechanism Resolution: The first study to use dual-fluoroscopy to validate VSS efficacy based on millimeter-level changes in dynamic joint space (mJSW), overcoming the limitations of external kinetic surrogates (KAM). Deciphering "Non-Response": Elucidating how ankle stiffness and gait strategy (e.g., Toe-out) interfere with VSS mechanics, providing data to support future "zone-specific" stiffness customization. Safety Validation: Establishing the clinical advantage of VSS in preserving ankle stability compared to traditional wedges, promoting its translation as a superior conservative therapy.

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Published since: 2026-03-05 , Earliest start: 2026-03-05 , Latest end: 2026-09-30

Organization Knee Joint Articular Contact Kinematics

Hosts Jiang Ziang

Topics Medical and Health Sciences

Praktikum in Sport & Exercise Biomechanics (OYM, Cham)

Im Bereich Sport & Exercise Biomechanics suchen wir Unterstützung bei der Durchführung und Auswertung von wissenschaftlichen Messungen im Bewegungsanaly-selabor (Motion Capture und Kraftmessplatten).

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Published since: 2026-02-27 , Earliest start: 2026-04-01 , Latest end: 2026-12-31

Organization Taylor Group / Laboratory for Movement Biomechanics

Hosts Zemp Roland, Dr.

Topics Medical and Health Sciences

Investigating trabecularization in response to intermittent parathyroid hormone therapy and mechanical loading during postmenopausal osteoporosis

The student project will investigate the bone response to intermittent parathyroid hormone (PTH) therapy after estrogen depletion with a specific focus on its capacity to induce trabecularization. The quantitative analysis of experimental in vivo micro-computed tomography scans will lead to new insights into the mechanisms of trabecularization and to define the contribution of mechanical stimulation in this process. The results are expected to advance mechanistic understanding of anabolic PTH therapy and inform the development of future patient-specific treatment strategies.

Keywords

Osteoporosis, parathyroid hormone therapy, mechanical loading, trabecular bone, python programming, R statistical evaluation

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Semester Project , Internship , Bachelor Thesis , Master Thesis

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Published since: 2026-02-24 , Earliest start: 2026-06-01 , Latest end: 2027-03-31

Organization Müller Group / Laboratory for Bone Biomechanics

Hosts Schulte Friederike

Topics Medical and Health Sciences , Information, Computing and Communication Sciences , Engineering and Technology

Automation and optimization of a melt electrowriting sytem for layered osteochondral scaffold fabrication

We are looking for a motivated master’s student to work on the automation and optimization of a melt electrowriting (MEW) system, with the aim of enabling the reproducible fabrication of layered scaffolds for osteochondral tissue engineering. The project combines machine-level development with biofabrication and scaffold design, focusing on improving process control and extending MEW toward mechanically integrated cartilage–bone constructs.

Keywords

Melt electrowriting (MEW) ; Biofabrication ; Osteochondral Scaffolds; Articular Cartilage; Subchondral Bone; Additive Manufacturing; Tissue Engineering; Scaffold Design

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Semester Project , Internship , Master Thesis , ETH Zurich (ETHZ)

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Published since: 2026-02-13 , Earliest start: 2026-02-23 , Latest end: 2026-08-28

Organization Tissue Mechanobiology

Hosts Amicone Alessio , Pizorn Jaka

Topics Engineering and Technology

How Sensory Neurons Shape Joint Function and Pain

Joint disorders and joint pain affect millions of people across all ages, yet the neuronal mechanisms that link joint mechanics to dysfunction and pain remain poorly understood. In this project, the student will explore how sensory neurons detect mechanical forces in musculoskeletal tissues and how altered sensing contributes to joint pathology and pain. The project integrates in vivo imaging, mouse genetics, and molecular profiling to study sensory neuron function during mechanical stimulation and disease. Working at the interface of neuroscience and biomechanics, the student will contribute to uncovering fundamental principles of joint somatosensation. This project is ideal for motivated students interested in sensory neuroscience, mechanobiology, and joint disorders, and offers hands-on experience with cutting-edge experimental approaches, merging biomechanics and neuroscience.

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Sensory neurons, Joint pain, Mechanosensation, In vivo imaging, Mouse genetics, Neuroscience, Biomechanics

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Semester Project , Internship , Master Thesis

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Published since: 2026-01-27 , Earliest start: 2026-01-01 , Latest end: 2026-11-01

Organization Snedeker Group / Laboratory for Orthopaedic Biomechanics

Hosts Passini Fabian

Topics Medical and Health Sciences , Engineering and Technology

Design and Development of a Bioelectronic Sensing Platform for Living Systems

This master’s thesis addresses the design and development of a bioelectronic sensing platform for the monitoring of three-dimensional biological constructs. The work focuses on electrical interfaces and hardware architectures to achieve stable, reproducible measurements in engineered tissue systems over extended periods.

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Bioelectronics, multi-electrode systems, engineered tissues, monitoring dynamics, experimental bioengineering

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Master Thesis

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Published since: 2026-01-26 , Earliest start: 2026-02-16 , Latest end: 2026-11-30

Applications limited to EPFL - Ecole Polytechnique Fédérale de Lausanne , ETH Zurich

Organization Qin Group / Biomaterials Engineering

Hosts Agrawal Prajwal

Topics Information, Computing and Communication Sciences , Engineering and Technology

Exploring the Mechanoregulation of Bone Regeneration

In over 100 years, the remarkable ability of bone to adapt to its mechanical environment has been a source of scientific fascination. Bone regeneration has been shown to be highly dependent on the mechanical environment at the fracture site. It has been demonstrated that mechanical stimuli can either accelerate or impede regeneration. Despite the fundamental importance of the mechanical environment in influencing bone regeneration, the molecular mechanisms underlying this phenomenon are complex and poorly understood.

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Bone, Mechanobiology, Spatial transcriptomics, Gene expression, Finite element modelling, Image processing

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Semester Project , Internship , Bachelor Thesis , Master Thesis

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Published since: 2026-01-19 , Earliest start: 2026-01-19 , Latest end: 2026-08-31

Organization Müller Group / Laboratory for Bone Biomechanics

Hosts Mathavan Neashan

Topics Medical and Health Sciences , Engineering and Technology