Prof. Ralph Müller
Development of a Heterocellular Human Bone Organoid for Precision Medicine and Treatment
Our goal is to establish a heterocellular 3D printed bone organoid model comprising all major bone cell types (osteoblasts, osteocytes, osteoclasts) to recapitulate bone remodeling units in an in vitro system. The organoids will be produced with the human cells, as they could represent human pathophysiology better than animal models, and eventually could replace them. These in vitro models could be used in the advancement of next-generation personalised treatment strategies. Our tools are different kinds of 3D bioprinting platforms, bio-ink formulations, hydrogels, mol-bioassays, and time-lapsed image processing of micro-CT scans.
Keywords
3D printing, bone organoids, co-culture, bioreactor, hydrogels, drug testing
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Semester Project , Internship , Bachelor Thesis , Master Thesis , ETH Zurich (ETHZ)
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Published since: 2026-06-01 , Earliest start: 2026-07-01 , Latest end: 2027-07-01
Organization Müller Group / Laboratory for Bone Biomechanics
Hosts Steffi Chris
Topics Engineering and Technology , Biology
Investigating trabecularization in response to intermittent parathyroid hormone therapy and mechanical loading during postmenopausal osteoporosis
The student project will investigate the bone response to intermittent parathyroid hormone (PTH) therapy after estrogen depletion with a specific focus on its capacity to induce trabecularization. The quantitative analysis of experimental in vivo micro-computed tomography scans will lead to new insights into the mechanisms of trabecularization and to define the contribution of mechanical stimulation in this process. The results are expected to advance mechanistic understanding of anabolic PTH therapy and inform the development of future patient-specific treatment strategies.
Keywords
Osteoporosis, parathyroid hormone therapy, mechanical loading, trabecular bone, python programming, R statistical evaluation
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Semester Project , Internship , Bachelor Thesis , Master Thesis
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Published since: 2026-05-28 , Earliest start: 2026-07-01 , Latest end: 2027-03-31
Organization Müller Group / Laboratory for Bone Biomechanics
Hosts Schulte Friederike
Topics Medical and Health Sciences , Information, Computing and Communication Sciences , Engineering and Technology
Spatial Proteomics of Mechanically-Driven Bone Healing
Bone healing is profoundly influenced by its mechanical environment. Advances in spatial proteomics now allow us to map protein expression within intact tissue and directly relate it to local biomechanical cues. The Laboratory for Bone Biomechanics is developing a new line of research within spatial mechanomics (DOI: 10.1126/sciadv.adp8496), integrating spatially resolved proteomic data with in silico models of the mechanical environment at fracture sites. This approach enables us to investigate, at cellular resolution, how mechanical forces shape protein-level signalling during bone repair.
Keywords
Bone, Mechanobiology, Spatial Proteomics, Protein Expression, Aging, Sex Differences, Mechanical Loading, Finite Element Modelling, Image Analysis
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Semester Project , Internship , Bachelor Thesis , Master Thesis
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Published since: 2026-04-28 , Earliest start: 2025-12-01 , Latest end: 2026-12-31
Organization Müller Group / Laboratory for Bone Biomechanics
Hosts Mathavan Neashan
Topics Medical and Health Sciences , Engineering and Technology , Biology
Exploring the Mechanoregulation of Bone Regeneration
In over 100 years, the remarkable ability of bone to adapt to its mechanical environment has been a source of scientific fascination. Bone regeneration has been shown to be highly dependent on the mechanical environment at the fracture site. It has been demonstrated that mechanical stimuli can either accelerate or impede regeneration. Despite the fundamental importance of the mechanical environment in influencing bone regeneration, the molecular mechanisms underlying this phenomenon are complex and poorly understood.
Keywords
Bone, Mechanobiology, Spatial transcriptomics, Gene expression, Finite element modelling, Image processing
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Semester Project , Internship , Bachelor Thesis , Master Thesis
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Published since: 2026-01-19 , Earliest start: 2026-01-19 , Latest end: 2026-08-31
Organization Müller Group / Laboratory for Bone Biomechanics
Hosts Mathavan Neashan
Topics Medical and Health Sciences , Engineering and Technology